The diagnosis of CIRS is established if the patient meets all the criteria above:
- Abnormalities documented by Visual Contrast Sensitivity (VCS) tests.
- A genetic predisposition to biotoxin-related illness, on the basis of an identification of an HLA susceptible haplotype.
- History, symptoms, and signs of biotoxin exposure. The history should involve exposure to toxin-producing molds as documented by the EPA-approved ERMI testing. Also, in the case of microcystin, ciguatera, etc., the history involves likely exposure or laboratory evidence of exposure.
- Biomarkers consistent with the vascular, neuroimmune, and endocrine abnormalities specific to CIRS. In the case of consistent biotoxin exposure, an abnormal VCS test, or a susceptible genotype, you will probably show the laboratory abnormalities seen in CIRS.